SrasV1, France, Analysis, bibRecord, 000147

SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets

Identifieur interne : 000147 ( France/Analysis ); précédent : 000146; suivant : 000148

SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets

Auteurs : Lorenzo Subissi [France] ; Isabelle Imbert [France] ; François Ferron [France] ; Axelle Collet [France] ; Bruno Coutard [France] ; Etienne Decroly [France] ; Bruno Canard [France]

Source :

Antiviral research [ 0166-3542 ] ; 2014.

RBID : Pascal:14-0035787

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Protéine, Enzyme, Antiviral, Cible, Ciblage, Réplication, Transcription.
Wicri :
- topic : Enzyme.

English descriptors

KwdEn :
- Antiviral, Enzyme, Protein, Replication, Severe acute respiratory syndrome virus, Target, Targeting, Transcription.

Abstract

The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replication-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27-32 kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, i.e., the main RNA-dependent RNA polymerase (nsp12), the helicase/triphosphatase (nsp13), two unusual ribonucleases (nsp14, nsp15) and RNA-cap methyltransferases (nsp14, nsp16). We also review how these enzymes co-operate with other viral co-factors (nsp7, nsp8, and nsp10) to regulate their activity. These last ten years of research on SARS-CoV have considerably contributed to unravel structural and functional details of one of the most fascinating replication/transcription machineries of the RNA virus world. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses".

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000016
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to stream PascalFrancis, to step Checkpoint: 000003
to stream Main, to step Merge: 001790
to stream Main, to step Curation: 001784
to stream Main, to step Exploration: 001784
to stream France, to step Extraction: 000147

Links to Exploration step

Pascal:14-0035787

Le document en format XML

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<front><div type="abstract" xml:lang="en">The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replication-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27-32 kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, i.e., the main RNA-dependent RNA polymerase (nsp12), the helicase/triphosphatase (nsp13), two unusual ribonucleases (nsp14, nsp15) and RNA-cap methyltransferases (nsp14, nsp16). We also review how these enzymes co-operate with other viral co-factors (nsp7, nsp8, and nsp10) to regulate their activity. These last ten years of research on SARS-CoV have considerably contributed to unravel structural and functional details of one of the most fascinating replication/transcription machineries of the RNA virus world. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses".</div>
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SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets

SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri